Celecoxib inhibited activation of NF-kB and expression of NF-kB P65 protein in HepG2 cells

Human Cytomegalovirus Upregulates NF-kB Activity by Transactivating the NF-kB p105/p50 and p65 Promoters

During human cytomegalovirus (HCMV) infection, a series of regulated events take place following virus binding and entry into the cell, including the upregulation of cellular transcription factors, such as NF-kB, which play an essential role in the viral life cycle. We show here that NF-kB message is induced during HCMV infection and that the induction is biphasic, suggesting an initial inducti...

The effects of adenosine injection after of brain ischemia reperfusion injury on gene expression of NF-kB/p65 and activity level of ROS in male Wistar rats

Background: Unit of p65 is one of the subunits of NF-κB and its phosphorylation by stress oxidative causes activation of NF-κB. The aim of present study was to investigate the effects of adenosine injection after brain ischemia reperfusion injury on gene expression of NF-κB /p65 and Reactive Oxygen Species (ROS) in hippocampus tissue of male wistar rats. Methods: 40 male wistar rats were rando...

NF-kB Expression in IgA Nephropathy Outcome

Some studies have demonstrated the involvement of nuclear factor-kappa B (NF-kB) in the pathogenesis of glomerulonephritis. The aim of our study was twofold: (1) to analyze the prognostic value of NF-kB expression in primary IgA nephropathy (IgAN) and (2) to compare the results of NF-kB expression by immunohistochemistry (IHC) and southwestern histochemistry (SWH). We analyzed 62 patients diagn...

Anergic CD8 T Lymphocytes Have Impaired NF-kB Activation with Defects in p65 Phosphorylation and Acetylation

Ser276 Phosphorylation of NF-kB p65 by MSK1 Controls SCF Expression in Inflammation

Transcription of the mast cell growth factor SCF (stem cell factor) is upregulated in inflammatory conditions, and this is dependent upon NF-kappaB, as well as the MAP kinases p38 and ERK activation. We show here that the MAPK downstream nuclear kinase MSK1 induces NF-kappaB p65 Ser276 phosphorylation upon IL-1beta treatment, which was inhibited in cells transfected with a MSK1 kinase-dead (KD)...